Tricyclic antidepressants (TCA)

Tricyclic antidepressants (TCAs) are a class of medication used to treat depression and other mental health conditions.

Tricyclic antidepressants

WHAT Is it?

Tricyclic antidepressants are a class of medication that has been used for decades to treat depression and other mental health conditions. They were first introduced in the 1950s and were the primary treatment for depression until the development of newer medications in the 1980s and 1990s.

TCAs work by blocking the reuptake of neurotransmitters such as serotonin and norepinephrine, increasing the amount of these chemicals in the brain and improving mood.

While physicians may prescribe Tricyclic Antidepressants (TCAs) for Major Depressive Disorder (MDD), they are seldom suggested as the initial course of treatment due to their adverse effects, which include anticholinergic, antihistamine, and antiadrenergic effects. Additionally, there are numerous safer alternatives, such as Selective Serotonin Reuptake Inhibitors (SSRIs), that are readily available.

how is it ingested?

Tricyclic antidepressants are typically taken orally as a tablet. The dosage and frequency of administration may vary depending on the patient's condition, type of drug, and response to treatment.


Tricyclic antidepressants are associated with a risk of overdose, particularly when combined with other drugs or alcohol. TCA overdose symptoms include arrhythmia, hypotension, convulsions, tremors, coma, xerostomia, urine retention, and respiratory depression.

Additionally, tricyclic antidepressants can be highly addictive and can lead to physical dependence with long-term use. Abruptly stopping the medication can also cause withdrawal symptoms. According to a study published by Cambridge University, TCAs account for 12 deaths per million prescriptions and 80% of deaths are due to suicides.


Tricyclic antidepressants are typically available in tablet form, and their appearance can vary depending on the specific medication. They may be small and round or oval and may come in different colors depending on the manufacturer.

what are its effects?

Tricyclic antidepressants can produce various effects, including improved mood, reduced anxiety, and improved sleep. They may take several weeks to start working, and it is important to continue taking them as prescribed even if there is no immediate improvement in symptoms. The most common side effects of TCAs include dry mouth, constipation, blurred vision, dizziness, and drowsiness.

Street Names

Tricyclic antidepressants are not commonly known by street names, as they are typically obtained through a prescription. However, they may be sold illicitly or obtained through fraudulent prescriptions.

TCAs that have FDA approval to treat the major depressive disorder include amitriptyline, amoxapine, doxepin, desipramine, nortriptyline, protriptyline, imipramine, and trimipramine.

Tricyclic antidepressants
Tricyclic antidepressants


Tricyclic Antidepressants on a drug test kit are known as TCA. The cut-off concentration is at 1000 ng/mL, and detection time is 1-2 days from previous use. It is useful to test for TCA in an emergency toxicology screening, because combining it with some medications could be fatal.

drug test kits

We offer many types of drug test kits and configurations that include Tricyclic Antidepressants. Doctors stopped prescribing them in favor of safer alternatives, so they are not as common as they used to be in the past.

View products with TCA below:

Drug Test Kits

DrugTestKitUSA Payments built in partnership with Stripe

Security at Stripe: Learn how Stripe handles security.

A PCI-certified auditor has audited Stripe. We’re a certified PCI Service Provider Level 1. This is the most stringent level of certification available in the payments industry. To accomplish this, we use the best-in-class security tools and practices to maintain a high level of security at Stripe.

HTTPS and HSTS for secure connections

Stripe forces HTTPS for all services using TLS (SSL), including our public website and the Dashboard to ensure secure connections:

  • Stripe.js is served only over TLS.
  • Stripe’s official libraries connect to Stripe’s servers over TLS and verify TLS certificates on each connection.

We regularly audit the details of our implementation, including the certificates we serve, the certificate authorities we use, and the ciphers we support. We use HSTS to ensure that browsers interact with Stripe only over HTTPS. Stripe is also on the HSTS preloaded lists for both Google Chrome and Mozilla Firefox.

Sensitive data and communication encryption

All card numbers are encrypted at rest with AES-256. Decryption keys are stored on separate machines. None of Stripe’s internal servers and daemons can obtain plain text card numbers but can request that cards are sent to a service provider on a static allowlist. Stripe’s infrastructure for storing, decrypting, and transmitting card numbers runs in a separate hosting environment, and doesn’t share any credentials with Stripe’s primary services including our API and website.

DrugTestKitUSA Accepts PayPal

Why use PayPal?

Your information is secured.

When you pay with PayPal, your financial information is never shared with the seller, and you can pay using only your email address and password.

Security around the clock.
PayPal monitors every transaction 24/7 to help prevent against fraud, email phishing and identity theft. Every transaction is heavily guarded behind their next-level encryption.

If something seems suspicious, their dedicated team of security specialists is immediately on it to help protect you from fraudulent transactions. And remember, PayPal will never ask for any sensitive information from you in an email.

You can be sure that your transaction is protected and secure when you use PayPal at the DrugTestKitUSA checkout.